The secret behind mysterious smile of Mona Lisa is discovered by scientists recently. The noticeable fact was the constituents of painting and the way Leonardo da Vinci had applied. Surprisingly, forty layer of glaze with various pigments and use of various other chemicals in one painting to create a shadow effect around the smile of Mona Lisa proves the greatness of the painter. I am surprise by a fact that some of the glaze took months to dry which means some of the effects could have been seen only after few years of the completion of the painting. The question is whether Leonardo da Vinci was aware of this and did purposefully or its a gifted outcome of a genius work. Nevertheless its an outstanding example of both creativity and innovation.